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Liquid Chromatography with Mass Spectrometry Detection (LC-MS) is a popular technique at M-Scan. Both Electrospray Ionization (ES-MS) and Atmospheric Pressure Chemical Ionisation (APCI) are available ensuring the maximum range of compounds can be analysed. Typical applications for these techniques include:
- Pharmaceutical, pharmacokinetics, biochemical and proteomic analysis including the quantitative analysis of drugs and metabolites
- Separation of mixtures to allow concomitant molecular weight determination
- ‘Mapping’ of digest mixtures and disulphide bridge analysis including corrosion and scale inhibitors
- Intact molecular weight determination for protein and glycoprotein
- Identification of impurities and degradants
- Analysis of polar, high boiling or thermally labile compounds
- Analysis of detergents used as additives in fuel
- Analysis of detergents found as carcinogenic environmental contaminants e.g. PFOS from firefighting foams
- Determination of the effectiveness of oilfield chemicals
- Significant increase in specificity over HPLC alone
M-Scan in brief:
M-Scan has unrivalled expertise and experience as a problem-solving contract research laboratory. We are specialists in Mass Spectrometry, Chromatography and associated techniques for solving the most demanding problems in organic chemical analysis. We have a multi-disciplinary analytical team, specialising in the fields of biotechnology, pharmaceutical, industrial, environmental and forensic chemistry. We are at the cutting-edge of developing new and bespoke analytical techniques and have a large collection of validated proprietary methods. We are experts in the interpretation of analytical data.
M-Scan Brochure: Biotechnology and Pharmaceutical Analysis (8pp.)