Circular Dichroism - M-Scan’s Wokingham facility is the first in the UK to offer GLP/GMP-compliant Circular Dichroism Analysis (CD), and the first to install Jasco’s latest CD Spectropolarimeter, the J-815, with class leading optical performance versatile for a range of applications, including:
- Protein folding and conformational studies (secondary structure)
- DNA/RNA interactions
- Enzyme kinetics
- Purity testing of optically active substances
- Quantitative analysis of pharmaceuticals
- Natural organic chemistry
- Biochemistry and macromolecules
- Rapid scanning (time resolved) experiments
This is a significant enhancement to M-Scan’s Product Characterisation Package, tailored to the ICH Q6B guideline which require Spectroscopic Profiling as part of the assessment of the physicochemical properties of a product. All new biotechnological or biological products need spectroscopic profiling as proof of conformance to gain regulatory approval.
M-Scan also offers research level NMR for spectroscopic profiling.
 | < />
 |
| Near UV CD 'Fingerprinting' of different batches of the same product | < />
Far UV Circular Dichroism of different batches |
M-Scan Brochure: Biotechnology and Pharmaceutical Analysis (8pp.)